I like Earl Pitts thought this was a made up diseases created by drug companies to push more pills on the population. Not so, it is indeed a real ailment and I have seen the effects personally. So what do you do, how do you know if you just have tired legs or something more. It's worth taking a minute to read into this to at least find your peace of mind.

Many people with RLS report that their job, personal relations, and activities of daily living are strongly affected as a result of their sleep deprivation. They are often unable to concentrate, have impaired memory, or fail to accomplish daily tasks. It also can make traveling difficult and can cause depression.

(via Restless Legs Syndrome Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS).)